Vinyl Chloride And Hcc

Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s.

Vinyl chloride and hcc.

Vinyl chloride and hcc the most up to date and most comprehensive analyses is a pooled analyses of cohorts of vcm workers from plants in the usa and europe 41. The most up to date and most comprehensive analy ses is a pooled analyses of cohorts of vcm workers from. Objective to evaluate mortality risks of angiosarcoma of the liver asl primary hepatocellular carcinoma hcc and other cancers among 9951 men employed between 1942 and 1972 at 35 us vinyl chloride vc or polyvinyl chloride plants followed for mortality through 31 december 2013. In vc associated las mutations of the k ras 2 gene have been reported.

Vinyl chloride is primarily used to make polyvinyl chloride to manufacture plastics. Methods smr and time dependent cox proportional hazards analyses were used to evaluate mortality risks by. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though only on the basis of the few cases available. The results from the two large multicenter studies and the pooled meta analysis are presented in table 2.

In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though o. Vinyl chloride is extensively used in the plastic industry and it is a well recognized risk factor for development of asl which is an extremely rare neoplasia when not associated with vc exposure. Vinyl chloride is an organochloride with the formula h 2 c chcl that is also called vinyl chloride monomer vcm or chloroethene this colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride pvc. About 13 billion kilograms are produced annually.

Plants in the usa and europe 41. Vinyl chloride vc is a know animal and human carcinogen associated with liver angiosarcomas las and hepatocellular carcinomas hcc. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. 2 after the first report of three cases of asl in subjects employed in the manufacture of pvc resins 15 epidemiological.

However no data about the prevalence of such mutations in vc associated hccs are available recent data indicate k ras 2 mutations induce p16 methylation accompanied by inactivation of. Vinyl chloride and hcc. The results from the.